The effects of field stimulation on bovine mesenteric lymph node contractility.
作者： J. G. McGeown , M. J. P. Gallagher
DOI: 10.1007/BF00370613
关键词: Peripheral nervous system 、 Phentolamine 、 Propranolol 、 Excitatory postsynaptic potential 、 Contractility 、 Stimulation 、 Internal medicine 、 Tetrodotoxin 、 Isometric exercise 、 Medicine 、 Endocrinology
摘要: In these studies isometric tension was recorded from isolated strips of bovine mesenteric lymph node capsule. The possible influence intrinsic nerves on their contractile activity examined using field stimulation and the pharmacology response investigated. Over 75% tissues studied demonstrated regular spontaneous at a frequency 3.9±0.2 contractions/5 min under control conditions. Field 2, 8 32 Hz (pulse width = 0.3 ms, nominal voltage 60 V) produced frequency-dependent increases in rate this associated with raised baseline tension. These responses were not diminished repeat contraction to blocked completely presence 1 μM tetrodotoxin, while increase reduced by over 80%, suggesting that activating nerves. (8 Hz) also greatly 10 phentolamine but unaffected propranolol. experiments suggest can modulate capsule acting, least part, through excitatory α-adrenoceptors. functional significance is discussed.
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