Factor V Leiden and Risks of Recurrent Idiopathic Venous Thromboembolism
作者： Paul M Ridker , Joseph P Miletich , Meir J Stampfer , Samuel Z Goldhaber , Klaus Lindpaintner
DOI: 10.1161/01.CIR.92.10.2800
关键词: Medicine 、 Embolism 、 Surgery 、 Pulmonary embolism 、 Factor V Leiden 、 Thrombophlebitis 、 Incidence (epidemiology) 、 Risk factor 、 Internal medicine 、 Factor V 、 Prospective cohort study
摘要: Background Whether Leiden mutation in the gene coding for coagulation factor V is associated with recurrent idiopathic venous thromboembolism (VTE) unknown, but such data are necessary to evaluate merits of genetic screening secondary prevention thromboembolic disease. Methods and Results Among 14 916 apparently healthy men who provided DNA samples were followed Physicians’ Health Study through August 1994, 77 suffered an VTE. These additional average period 68.3 months, during which time 11 (14.3%) a Factor status was assessed these men, incidence rates recurrence calculated by genotype. All events occurred after cessation anticoagulation. Seven recurrences among 63 genetically unaffected subjects (11.1%; rate, 1.82 per 100 person-years), while four those heterozygous (28.6%; 7.46 person-y...
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