Delayed neurotoxic complication of intracavitary bleomycin therapy for craniopharyngioma in a child who had previously undergone radiosurgery

摘要: Local administration of bleomycin for the treatment craniopharyngioma is occasionally associated with serious regional complications. The authors report a case delayed neurotoxic complication in patient who had previously undergone radiosurgery. A 14-year-old boy presented cyst recurrence mixed-type craniopharyngioma. An Ommaya device was placed thin-walled cyst, and after confirmation that watertight, received total dose 75 mg intratumorally during 5-week period. Six weeks final drug administration, experienced complex partial epileptic seizures; few days later sudden right temporal hemianopia developed. Within 5 became totally blind his eye, condition did not respond to corticosteroid therapy. Although drug-related toxic complications occur commonly course intracavitary treatment, they may also be encountered follow-up reason this could have been previous radiotherapy or hypersensitivity tumor capsule drug.