Circulating ANGPTL8/Betatrophin Is Increased in Obesity and Reduced after Exercise Training
作者： Mohamed Abu-Farha , Devarajan Sriraman , Preethi Cherian , Irina AlKhairi , Naser Elkum
DOI: 10.1371/JOURNAL.PONE.0147367
关键词: Endocrinology 、 Blood pressure 、 Triglyceride 、 Glucose homeostasis 、 Blood plasma 、 Peptide hormone 、 Betatrophin 、 Body mass index 、 Medicine 、 Internal medicine 、 Adipose tissue 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Objective ANGPTL8 is a liver and adipose tissue produced protein that regulates the level of triglyceride in plasma as well glucose homeostasis. This study was designed to evaluate ANGPTL8 obese non-obese subjects before after exercise training. Methods A total 82 62 adult were enrolled this study. Subjects underwent three months training. Both full length C-terminal 139–198 form measured by ELISA. Results Our data show increased (1150.04 ± 108.10 pg/mL) compared (775.54 46.12) pg/mL (p-Value = 0.002). also 0.28 0.04 ng/mL vs 0.20 0.02 (p-value 0.058). In subjects, levels both forms reduced training; from 1150.04 852.04 51.95 (p-Values 0.015) c-terminal 0.19 0.03 Interestingly, positively associated with fasting blood (FBG) (r 0.317, p-Value 0.006) 0.346, on other hand, did not any correlation groups. Conclusion In conclusion, our demonstrate obesity training supporting potential therapeutic benefit reducing ANGPTL8. The various differently FBG suggesting they have different roles
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Susan Bonner-Weir, Gordon C Weir, New sources of pancreatic beta-cells. Nature Biotechnology. ,vol. 23, pp. 857- 861 ,(2005) , 10.1038/NBT1115
Kaifeng Guo, Junxi Lu, Haoyong Yu, Fangya Zhao, Pan Pan, Lei Zhang, Haibing Chen, Yuqian Bao, Weiping Jia, Serum betatrophin concentrations are significantly increased in overweight but not in obese or type 2 diabetic individuals. Obesity. ,vol. 23, pp. 793- 797 ,(2015) , 10.1002/OBY.21038
Ren Zhang, Abdul B. Abou-Samra, Emerging roles of Lipasin as a critical lipid regulator. Biochemical and Biophysical Research Communications. ,vol. 432, pp. 401- 405 ,(2013) , 10.1016/J.BBRC.2013.01.129
Viktoria Gusarova, Corey A. Alexa, Erqian Na, Panayiotis E. Stevis, Yurong Xin, Susan Bonner-Weir, Jonathan C. Cohen, Helen H. Hobbs, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada, ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion Cell. ,vol. 159, pp. 691- 696 ,(2014) , 10.1016/J.CELL.2014.09.027
Zhenqi Liu, Chao Zheng, Vascular function, insulin action, and exercise: an intricate interplay Trends in Endocrinology and Metabolism. ,vol. 26, pp. 297- 304 ,(2015) , 10.1016/J.TEM.2015.02.002
Mohamed Abu-Farha, Ali Tiss, Jehad Abubaker, Abdelkrim Khadir, Fahad Al-Ghimlas, Irina Al-Khairi, Engin Baturcam, Preethi Cherian, Naser Elkum, Maha Hammad, Jeena John, Sina Kavalakatt, Samia Warsame, Kazem Behbehani, Said Dermime, Mohammed Dehbi, Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0075342
Peng Yi, Ji-Sun Park, Douglas A. Melton, Perspectives on the activities of ANGPTL8/betatrophin. Cell. ,vol. 159, pp. 467- 468 ,(2014) , 10.1016/J.CELL.2014.09.028
Jiaxi Chen, Shuyuan Chen, Pintong Huang, Xing-Li Meng, Sandra Clayton, Jin-Song Shen, Paul A. Grayburn, In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats. Diabetologia. ,vol. 58, pp. 1036- 1044 ,(2015) , 10.1007/S00125-015-3521-Z
Ren Zhang, Abdul B Abou-Samra, A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy. Cardiovascular Diabetology. ,vol. 13, pp. 133- 133 ,(2014) , 10.1186/S12933-014-0133-8
Hodaka Yamada, Tomoyuki Saito, Atsushi Aoki, Tomoko Asano, Masashi Yoshida, Aki Ikoma, Ikuyo Kusaka, Hideo Toyoshima, Masafumi Kakei, San-e Ishikawa, Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes Endocrine Journal. ,vol. 62, pp. 417- 421 ,(2015) , 10.1507/ENDOCRJ.EJ14-0525