Cell Surface Molecular Chaperones and the LPS Receptor

摘要: Heat shock proteins are ancient, highly conserved, molecular chaperones essential for maintaining cellular functions. Although originally thought to be only intracellular, it has become apparent that they exist on the surfaces of cells and in extracellular space able modulate both innate adaptive immune responses. They have been shown ability trigger inflammatory responses similar pathogen-associated patterns (PAMPs), act as “danger” signals” response (DAMPs) inhibit or resolve inflammation (so-called—resolution-associated patterns—RAMPs). Therefore their role immunity seems multifunctional. In this chapter, we will focus how these involved interact with pattern recognition receptors microbial pathogens.