Regional Specific Evidence for Memory-Load Dependent Activity in the Dorsal Subiculum and the Lateral Entorhinal Cortex.

摘要: The subiculum and the lateral entorhinal cortex (LEC) are main output areas of hippocampus which contributes to spatial non-spatial memory. proximal part (bordering CA1) receives heavy projections from perirhinal distal CA1 subiculum), both known for their ties object recognition However, extent memory is still unclear. Comparatively, involvement LEC in information processing quite well known. very few studies have investigated its role within frame function. Thus, it not whether contribution depends on load. In addition, deep layers EC been shown be predictive subsequent performance, but superficial layers. Hence, here we tested contribute memory, this load task. To do so, imaged brain activity at cellular resolution these rats performing a delayed nonmatch sample task based odors with two different loads (5 or 10 odors). This imaging technique detection RNA immediate-early gene Arc, especially tied synaptic plasticity behavioral demands, commonly used map medial temporal lobe. We report first time that recruited memory-load dependent manner engaged under high conditions during retrieval thus shedding light specific networks contributing retrieval.