Connexins-Based Hemichannels/Channels and Their Relationship with Inflammation, Seizures and Epilepsy.

摘要: Connexins (Cxs) are a family of 21 protein isoforms, eleven which expressed in the central nervous system, and they found neurons glia. Cxs form hemichannels (connexons) channels (gap junctions/electric synapses) that permit functional metabolic coupling between astrocytes. Altered Cx expression function is involved inflammation neurological diseases. Cxs-based have relevance to seizures epilepsy two ways: First, this pathological condition increases opening probability glial cells enable gliotransmitter release, sustaining inflammatory process exacerbating seizure generation epileptogenesis, second, favors excitability synchronization through coupled neurons. These biological events highlight global mechanism epilepsy, therapeutic potential channels. Therefore, review describes role neuroinflammation examines how blocking may be targets anti-convulsive anti-epileptic treatments.