trans Fatty acids in human milk are inversely associated with concentrations of essential all-cis n−6 and n−3 fatty acids and determine trans, but not n−6 and n−3, fatty acids in plasma lipids of breast-fed infants

作者: Sheila M Innis , D Janette King

DOI: 10.1093/AJCN/70.3.383

关键词: Animal nutritionFood scienceFatty acidBiochemistryBreast milkLinoleic acidUnsaturated fatty acidDocosahexaenoic acidChemistryArachidonic acidMetabolism

摘要: BACKGROUND Human milk fatty acids vary with maternal dietary fat composition. Hydrogenated oils trans may displace cis n-6 and n-3 unsaturated or have adverse effects on their metabolism. The of trans, n-6, in breast-fed infants are unclear, although important infant growth development. OBJECTIVE We sought to determine the relations between plasma phospholipids triacylglycerols infants, identify major sources acids. DESIGN collected from 103 mothers exclusively 2-mo-old blood 62 3-d records 21 mothers. RESULTS Mean (+/-SEM) percentages were as follows: milk, 7.1 +/- 0.32%; infants' triacylglycerols, 6.5 0. 33%; phospholipids, 3.7 0.16%. Milk acids, alpha-linolenic acid (18:3n-3), arachidonic (20:4n-6), docosahexaenoic (22:6n-3) (P < 0.001), linoleic (18:2n-6) = 0.007) each related same phospholipids. inversely 18:2n-6 18:3n-3, but not 20:4n-6 22:6n-3. Fatty represented 7.7% total intake (2.5% energy); bakery products breads (32%), snacks (14%), fast foods (11%), margarines shortenings (11%). CONCLUSIONS There comparable concentrations diet, breast infants. Prepared source

参考文章(33)
Sheila M. Innis, Polyunsaturated Fatty Acid Nutrition in Infants Born at Term Developing Brain Behaviour#R##N#The Role of Lipids in Infant Formula. pp. 103- 167 ,(1997) , 10.1016/B978-012218870-1/50005-1
Susan E. Carlson, Long-chain Polyunsaturated Fatty Acid Supplementation of Preterm Infants Developing Brain Behaviour#R##N#The Role of Lipids in Infant Formula. pp. 41- 102 ,(1997) , 10.1016/B978-012218870-1/50004-X
M.B. Katan, Isomeric trans fatty acids in the US diet. Journal of The American College of Nutrition. ,vol. 10, pp. 519- 519 ,(1991)
J E Hunter, T H Applewhite, Reassessment of trans fatty acid availability in the US diet. The American Journal of Clinical Nutrition. ,vol. 54, pp. 363- 369 ,(1991) , 10.1093/AJCN/54.2.363
B Koletzko, M Mrotzek, H J Bremer, Fatty acid composition of mature human milk in Germany. The American Journal of Clinical Nutrition. ,vol. 47, pp. 954- 959 ,(1988) , 10.1093/AJCN/47.6.954
Bruce A. Watkins, Chwan-L. Shen, John P. McMurtry, Hui Xu, Steven D. Bain, Kenneth G. D. Allen, Mark F. Seifert, Dietary Lipids Modulate Bone Prostaglandin E2 Production, Insulin-Like Growth Factor-I Concentration and Formation Rate in Chicks Journal of Nutrition. ,vol. 127, pp. 1084- 1091 ,(1997) , 10.1093/JN/127.6.1084
S.F. Chin, W. Liu, J.M. Storkson, Y.L. Ha, M.W. Pariza, Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens Journal of Food Composition and Analysis. ,vol. 5, pp. 185- 197 ,(1992) , 10.1016/0889-1575(92)90037-K
Tamås Decsi, Berthold Koletzko, None, Do trans Fatty Acids Impair Linoleic Acid Metabolism in Children Annals of Nutrition and Metabolism. ,vol. 39, pp. 36- 41 ,(1995) , 10.1159/000177840
J. B. Ohlrogge, R. M. Gulley, E. A. Emken, Occurrence of octadecenoic fatty acid isomers from hydrogenated fats in human tissue lipid classes. Lipids. ,vol. 17, pp. 551- 557 ,(1982) , 10.1007/BF02535383
Walter C Willett, Meir J Stampfer, JE Manson, Graham A Colditz, Frank E Speizer, Bernard A Rosner, Charles H Hennekens, Laura A Sampson, Intake of trans fatty acids and risk of coronary heart disease among women The Lancet. ,vol. 341, pp. 581- 585 ,(1993) , 10.1016/0140-6736(93)90350-P