Animal Models of Osteochondral Defect for Testing Biomaterials.

摘要: The treatment of osteochondral defects (OCD) remains a great challenge in orthopaedics. Tissue engineering holds good promise for regeneration OCD. In the light tissue engineering, it is critical to establish an appropriate animal model evaluate degradability, biocompatibility, and interaction implanted biomaterials with host bone/cartilage tissues OCD repair vivo. Currently, animals that are commonly deployed create lesions range from rats, rabbits, dogs, pigs, goats, sheep horses nonhuman primates. It essential understand advantages disadvantages each terms accuracy effectiveness experiment. Therefore, this review aims introduce common models testing discuss their applications translational research. addition, we have reviewed surgical protocols establishing promote regeneration. For small animals, non-load-bearing region such as groove femoral condyle chosen degradation, tissues. large closer clinical application, load-bearing (medial condyle) durability healing outcome biomaterials. This provides important reference selecting suitable development new strategies