Rising trends of symmetrical drug related intertriginous and flexural exanthem due to Itraconazole in patients with superficial dermatophytosis: A case series of 12 patients from eastern part of India

摘要: SDRIFE (symmetrical drug related intertriginous and flexural exanthem) is a benign self-limiting adverse reaction (ADR) primarily affecting the intertriginous, gluteal regions symmetrically in absence of systemic involvement. It considered to be variant baboon syndrome. Pathogenesis poorly understood but thought result delayed hypersensitivity response after exposure drug. Commonly implicated drugs are beta-lactam antibiotics. With rising incidence dermatophytosis Indian subcontinent, use oral anti fungals has become rampant. due itraconazole been rarely reported literature. We hereby present series 12 patients presenting with itraconazole, which by far largest existing This case highlights importance identifying these cutaneous reactions setting where commonly being used.