Complex networks of multiple factors in the pathogenesis of uterine leiomyoma

摘要: Objective To summarize the information regarding pathogenetic factors of leiomyoma formation and growth, to make a simple integrated view this tumor for further thinking establish new therapeutic options. Design PubMed Google Scholar searches were conducted identify relevant studies on pathogenesis uterine leiomyoma, which are hereby reviewed discussed. Setting Academic medical center. Patient(s) Not applicable. Intervention(s) Main Outcome Measure(s) Result(s) date, leiomyomas is not well understood. However, genetic alterations (especially MED12 HMGA2 ) involvement epigenetic mechanisms (DNA methylation, histone modifications, microRNA) in provide clue initiator tumor. Estrogens P considered as promoters growth factors, cytokines, chemokines thought be potential effectors estrogens P. Extracellular matrix components major structural part tissue that abnormally orientated can modify mechanical stress cells, leads activation internal signaling may contribute growth. Conclusion(s) Besides many genetics important link among sex steroids, chemokines, extracellular their cell proliferation, fibrotic processes, apoptosis, angiogenesis implicating complex network Those findings could future options management