Effects of N-acetyl-L-cysteine on lifespan, locomotor activity and stress-resistance of 3 Drosophila species with different lifespans.
作者： Mikhail V. Shaposhnikov , Nadezhda V. Zemskaya , Liubov A. Koval , Eugenia V. Schegoleva , Alex Zhavoronkov
关键词: Chemistry 、 Endocrinology 、 Antioxidant 、 Melanogaster 、 Hormesis 、 SOD1 、 Geroprotector 、 Longevity 、 Gene 、 Amino acid 、 Internal medicine
摘要: N-acetyl-L-cysteine (NAC) is a derivative of the sulphur-containing amino acid L-cysteine with potential anti-aging properties. We studied 3 Drosophila species contrast longevity differences (D. virilis longest-lived, D. kikkawai shortest-lived and melanogaster has moderate lifespan) to test effects NAC at 8 different concentrations (from 10 nM 100 mM) on lifespan, stress-resistance locomotor activity. Except adverse highest (10 mM demonstrated sexually opposite male-biased activity not satisfied criteria geroprotector in terms reproducibility lifespan extending model organisms. The concentration- sex-dependent changes relative expression levels antioxidant genes (Cat/CG6871 Sod1/CG11793) involved hydrogen sulfide biosynthesis (Cbs/CG1753, Eip55E/CG5345 Nfs1/CG12264) suggest involvement hormetic mechanisms geroprotective NAC.
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