A metabonomics approach as a means for identification of potential biomarkers for early diagnosis of endometriosis

作者: Mainak Dutta , Mamata Joshi , Sudha Srivastava , Indrani Lodh , Baidyanath Chakravarty

DOI: 10.1039/C2MB25353D

关键词: IsoleucineGastroenterologyMetabolomicsPathogenesisValineArginineBiochemistryEndometriosisBiologyLeucineInternal medicineAlanine

摘要: Our present study focuses on the identification of predictive biomarkers in serum for early diagnosis endometriosis a minimally invasive manner using 1H-NMR based metabonomics. PLS-DA modeling bins obtained from CPMG spectra samples discriminated patients controls with sensitivity and specificity levels about 80% 90%, respectively. Compared those controls, showed increased lactate, 3-hydroxybutyrate, alanine, leucine, valine, threonine, lysine, glycerophosphatidylcholine, succinic acid 2-hydroxybutyrate as well decreased lipids, glucose, isoleucine arginine. work offers valuable information non-invasive may be potential benefit to understand pathogenesis disease.

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