作者: Mainak Dutta , Mamata Joshi , Sudha Srivastava , Indrani Lodh , Baidyanath Chakravarty
DOI: 10.1039/C2MB25353D
关键词: Isoleucine 、 Gastroenterology 、 Metabolomics 、 Pathogenesis 、 Valine 、 Arginine 、 Biochemistry 、 Endometriosis 、 Biology 、 Leucine 、 Internal medicine 、 Alanine
摘要: Our present study focuses on the identification of predictive biomarkers in serum for early diagnosis endometriosis a minimally invasive manner using 1H-NMR based metabonomics. PLS-DA modeling bins obtained from CPMG spectra samples discriminated patients controls with sensitivity and specificity levels about 80% 90%, respectively. Compared those controls, showed increased lactate, 3-hydroxybutyrate, alanine, leucine, valine, threonine, lysine, glycerophosphatidylcholine, succinic acid 2-hydroxybutyrate as well decreased lipids, glucose, isoleucine arginine. work offers valuable information non-invasive may be potential benefit to understand pathogenesis disease.