Brunsvicamides A−C: Sponge-Related Cyanobacterial Peptides with Mycobacterium tuberculosis Protein Tyrosine Phosphatase Inhibitory Activity
作者： Daniela Müller , Anja Krick , Stefan Kehraus , Christian Mehner , Mark Hart
DOI: 10.1021/JM060327W
关键词: Microbiology 、 Enzyme 、 Cyclic peptide 、 Structural motif 、 Protein tyrosine phosphatase 、 Chemistry 、 Marine invertebrates 、 Antibacterial agent 、 Biological activity 、 Mycobacterium tuberculosis 、 Biochemistry
摘要: The cyanobacterium Tychonema sp. produces the new cyclic hexapeptides brunsvicamide A-C (1-3). Brunsvicamide B (2) and C (3) selectively inhibit Mycobacterium tuberculosis protein tyrosine phosphatase (MptpB), a potential drug target for therapy which no inhibitors are known to date. contains an N-methylated N'-formylkynurenine moiety, unique structural motif in peptides. peptides related sponge-derived mozamides, supporting suggestion that secondary metabolites of certain marine invertebrates produced by associated microorganisms. Thus, microorganisms phylogenetically symbionts can be judged as means supply "marine-like" compounds development.
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