Chromosome analysis of experimental rat glial tumor(1)--correlation of chromosome changes between glial tumors and fetal brain tissue of rats after a transplacental exposure to ethylnitrosourea.
作者： Makoto TANAKA , Satoshi MATSUMOTO
DOI: 10.2176/NMC.16PT1.35
关键词: Glioma 、 Medicine 、 Monosomy 、 Glial tumor 、 Pathology 、 Cell culture 、 Ethylnitrosourea 、 Chromosome 、 Marker chromosome 、 Transplacental 、 Anatomy
摘要: Chromosomal constitution of 7 rat glial tumors induced by methylnitrosourea (MNU) and ethylnitrosourea (ENU) was investigated. Cells from showed preferentially complete monosomy for # 3 chromosomes partial 2 chromosomes. Numerical morphological changes in 11 12 were also observed. These chromosome aberrations have no relation with histological classification experimental gial tumors. One missing neolplastic constantly observed through a long term culture had the appearance marker chromosome. compared preferential involvement 1 fetal brain cells rats shortly after transplacental administration ENU.
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