A Guide to HIV-1 Reverse Transcriptase and Protease Sequencing for Drug Resistance Studies.

摘要: HIV-1 RT and protease sequencing drug susceptibility testing have been done in research settings for more than ten years to elucidate the genetic mechanisms of resistance antiretroviral drugs. Retrospective studies shown that presence before starting a new regimen is an independent predictor virologic response (DeGruttola et al., 2000; Hanna D’Aquila, 2001; Haubrich Demeter, 2001). Prospective patients whose physicians access data, particularly genotypic respond better therapy control do not same data (Baxter Cohen De Luca Durant 1999; Melnick Meynard Tural 2000). The accumulation retrospective prospective has led three expert panels recommend use treatment HIV-infected (EuroGuidelines Group HIV Resistance, Hirsch US Department Health Human Services Panel on Clinical Practices Treatment Infection, 2000) (Table 1). There several recent reviews methods assessing (Demeter Haubrich, Richman, mutations associated with (Deeks, Hammond Loveday, Miller, Shafer 2000b). This review will detail where it used learn about clinical significance help guide anti-HIV treatment.