Neonatal sepsis: epidemiology, clinical spectrum, recent antimicrobial agents and their antibiotic susceptibility pattern

摘要: Background:  Neonatal sepsis is one of the most common causes neonatal mortality in developing world. This study aims to determine incidence, bacteriological profile septicaemia, their antibacterial susceptibility pattern. Methods: It a prospective study, carried out tertiary care NICU S.P. Medical College, Bikaner, Rajasthan, from January 2014 October 2014. Blood culture specimens were collected neonates, identification organisms, antibiotic pattern detection was done. Results: Gram negative organisms more (71.42%) than gram positive (28.57%). Klebsiella pathogen (48.21%) both early and late onset septicemia. In third generation cephalosporins, only organism (Strept. faecalis) sensitive ceftriaxone but cefoperazone cefotaxim have activity against Klebseilla coagulase Staphylococcus. Ceftazidime showed better results active Klebseilla, E. coli, pseudomonas unidentified bacilli. aminoglycosides amikacin has much gentamicin. Piperacillin had advantage over ampicillin. All except coli sensitivity cefotaxime. Vancomycin good (enterococcus, CONS, MRSA). rate 23.43%. Conclusions:  major morbidity newborns. Prematurity, low birth weight, prolonged rupture membranes are risk factors predisposing neonate sepsis. alarming patterns. The antibiotics which routinely used like ampicillin poor organisms.