Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis

摘要: The dopamine D3 receptor (D3R) is a target for developing medications to treat substance use disorders. D3R-selective compounds with high affinity and varying efficacies have been discovered, providing critical research tools cell-based studies that translated in vivo models of drug abuse. D3R antagonists partial agonists shown especially promising results rodent relapse-like behavior, including stress-, drug-, cue-induced reinstatement seeking. However, date, translation human has limited. Herein, we present an overview illustrate some the pitfalls challenges novel toward clinical utility, treatment cocaine Future development abuse remains critically important but will also require further evaluation translational animal determine best time addicti...