Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides

摘要: Many of the chemicals in common use possess, to some degree, a capacity cause skin sensitization. Consequently, it is important conduct thorough and accurate risk assessment when can be anticipated that such are likely come into contact with human skin. Such assessments must consider nature extent dermal exposure together sensitizing potency chemical. Whilst elements process often well understood, or at least reasonably predicted on basis proposed usage chemical, determination may problematic. In this paper, we describe an approach relative 3 isothiazolinone biocides. Initially, local lymph node assay (LLNA) provides estimate potency. Where appropriate, followed by confirmatory testing repeat insult patch test (HRIPT). The data generated reveal (chloro)methyl (CMI) significantly stronger sensitizer than either methyl trimethylene (MTI) benzisothiazolinone (BIT). Furthermore, both LLNA HRIPT show consistently BIT somewhat weaker MTI. As additional component safety evaluation, ability these isothiazolinones cross-react has been considered; indicate more weakly do not elicit allergic reactions subjects sensitized MCI. implications for biocides various product types discussed.