Blood borne: bacterial components in mother's blood influence fetal development.

摘要: Bacterial or viral infection of the mother during course pregnancy can cross placenta and actively infect fetus. However, especially for bacteria, it is more common mothers to experience an that be treated without overt fetal infection. In this setting, less well understood what risk development is, particularly in terms neurological development. This research highlight reviews recent findings indicating bacterial components generated activate innate immune system resulting changes brain subsequent progression postnatal cognitive disorders. cell wall a ubiquitous PAMP (pathogen-associated molecular pattern) known inflammation through stimulation TLR2. Cell released from bacteria antibiotic treatment new work shows embryos exposed demonstrate anomalous proliferation neuronal precursor cells TLR2 dependent manner. Such increases density cortical plate alters architecture. Although there no death, significantly impaired. model suggests its impact requires greater understanding potentially eliminate factor disorders such as autism.