Hepatic non-Hodgkin lymphoma and hepatoblastoma complicating ataxia-telangiectasia

摘要: Patients with ataxia-telangiectasia (A-T) have an increased risk of developing malignancies and are prone to severe early or late toxicity owing chemotherapy. Leukemia lymphoma account for about 85% malignancies, but solid tumors also been reported. We describe unusual case 8-year-old child affected by A-T, who presented a primary hepatic B-cell non-Hodgkin lymphoma, treated reduced doses R-CHOP cycles plus rituximab. Three years later, the patient developed hepatoblastoma as second malignancy. This clearly emphasizes need intensive monitoring A-T patients signs malignancy opportunity consider specific modified regimens