Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure.

作者: Tammo Müller , Christin Dewitz , Jessica Schmitz , Anna Sophia Schröder , Jan Hinrich Bräsen

DOI: 10.1007/S00018-017-2547-4

关键词: BiochemistryProgrammed cell deathFatty acid metabolismACSL4Cell typeDownregulation and upregulationEnzymeLipid peroxidationCell biologyNecroptosisBiology

摘要: … marker of ferroptosis execution. Overall, these data support the ideas that the interplay between the ferroptosis and necroptosis … M5, were analyzed by Western blotting for the ablation of …

参考文章(43)
Scott J. Dixon, Georg E. Winter, Leila S. Musavi, Eric D. Lee, Berend Snijder, Manuele Rebsamen, Giulio Superti-Furga, Brent R. Stockwell, Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death ACS Chemical Biology. ,vol. 10, pp. 1604- 1609 ,(2015) , 10.1021/ACSCHEMBIO.5B00245
Maria C Tanzer, Anne Tripaydonis, Andrew I Webb, Samuel N Young, Leila N Varghese, Cathrine Hall, Warren S Alexander, Joanne M Hildebrand, John Silke, James M Murphy, Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop Biochemical Journal. ,vol. 471, pp. 255- 265 ,(2015) , 10.1042/BJ20150678
Lorenzo Galluzzi, Oliver Kepp, Stefan Krautwald, Guido Kroemer, Andreas Linkermann, Molecular mechanisms of regulated necrosis Seminars in Cell & Developmental Biology. ,vol. 35, pp. 24- 32 ,(2014) , 10.1016/J.SEMCDB.2014.02.006
Andrew Oberst, Christopher P. Dillon, Ricardo Weinlich, Laura L. McCormick, Patrick Fitzgerald, Cristina Pop, Razq Hakem, Guy S. Salvesen, Douglas R. Green, Catalytic activity of the caspase-8–FLIP L complex inhibits RIPK3-dependent necrosis Nature. ,vol. 471, pp. 363- 367 ,(2011) , 10.1038/NATURE09852
William J. Kaiser, Haripriya Sridharan, Chunzi Huang, Pratyusha Mandal, Jason W. Upton, Peter J. Gough, Clark A. Sehon, Robert W. Marquis, John Bertin, Edward S. Mocarski, Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL Journal of Biological Chemistry. ,vol. 288, pp. 31268- 31279 ,(2013) , 10.1074/JBC.M113.462341
A. Linkermann, J. H. Brasen, M. Darding, M. K. Jin, A. B. Sanz, J.-O. Heller, F. De Zen, R. Weinlich, A. Ortiz, H. Walczak, J. M. Weinberg, D. R. Green, U. Kunzendorf, S. Krautwald, Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury Proceedings of the National Academy of Sciences of the United States of America. ,vol. 110, pp. 12024- 12029 ,(2013) , 10.1073/PNAS.1305538110
James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb, Samuel N Young, Leila N Varghese, Gillian M Tannahill, Esme C Hatchell, Ian J Majewski, Toru Okamoto, Renwick CJ Dobson, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola, Andreas Strasser, John Silke, Warren S Alexander, None, The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism Immunity. ,vol. 39, pp. 443- 453 ,(2013) , 10.1016/J.IMMUNI.2013.06.018
Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht, Rachid Skouta, Eleina M. Zaitsev, Caroline E. Gleason, Darpan N. Patel, Andras J. Bauer, Alexandra M. Cantley, Wan Seok Yang, Barclay Morrison, Brent R. Stockwell, Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death Cell. ,vol. 149, pp. 1060- 1072 ,(2012) , 10.1016/J.CELL.2012.03.042
Wan Seok Yang, Rohitha SriRamaratnam, Matthew E. Welsch, Kenichi Shimada, Rachid Skouta, Vasanthi S. Viswanathan, Jaime H. Cheah, Paul A. Clemons, Alykhan F. Shamji, Clary B. Clish, Lewis M. Brown, Albert W. Girotti, Virginia W. Cornish, Stuart L. Schreiber, Brent R. Stockwell, Regulation of Ferroptotic Cancer Cell Death by GPX4 Cell. ,vol. 156, pp. 317- 331 ,(2014) , 10.1016/J.CELL.2013.12.010
S. Mark Moran, Bryan D. Myers, Course of acute renal failure studied by a model of creatinine kinetics Kidney International. ,vol. 27, pp. 928- 937 ,(1985) , 10.1038/KI.1985.101