Anti-atherosclerotic effect of Farnesoid-X-Receptor in ApoE -/- mice

作者: Stefano Fiorucci , Barbara Renga , Andrea Mencarelli , Luisa Riccardi , Eleonora Distrutti

DOI:

关键词: LDL receptorFarnesoid X receptorRetinoid X receptorCholesterol 7 alpha-hydroxylaseChenodeoxycholic acidLiver X receptorEndocrinologyFatty acid synthaseCarnitine palmitoyltransferase IChemistryInternal medicine

摘要: Abbreviations: acetyl-CoA carboxylase (ACC); synthetase (AceCS); carnitine palmitoyltransferase I (CPT-I); chenodeoxycholic acid (CDCA); cholesterol 7 hydroxylase (CYP7A1); cholic (CA); farnesoid X receptor (FXR); fatty synthase (FAS); LDL (LDL-R); INT-747, 6ethyl-CDCA; liver (LXR; long-chain acyl-CoA dehydrogenase (LCAD); malic enzyme (ME); medium-chain acylCoA (MCAD); retinoid (RXR); short heterodimer partner (SHP); triglyceride (TG). Articles in PresS. Am J Physiol Heart Circ (November 21, 2008). doi:10.1152/ajpheart.01075.2008

参考文章(44)
Ajay Chawla, Yaacov Barak, Laszlo Nagy, Debbie Liao, Peter Tontonoz, Ronald M. Evans, PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nature Medicine. ,vol. 7, pp. 48- 52 ,(2001) , 10.1038/83336
HY Huh, SF Pearce, LM Yesner, JL Schindler, RL Silverstein, Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation. Blood. ,vol. 87, pp. 2020- 2028 ,(1996) , 10.1182/BLOOD.V87.5.2020.2020
Laetitia Dufort, Giovanna Chimini, ATP Binding Cassette Transporters High‐Density Lipoproteins. pp. 111- 142 ,(2007) , 10.1002/9783527625178.CH5
Haibo Wang, Jasmine Chen, Kevin Hollister, Lawrence C Sowers, Barry M Forman, Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Molecular Cell. ,vol. 3, pp. 543- 553 ,(1999) , 10.1016/S1097-2765(00)80348-2
Y Nakashima, A S Plump, E W Raines, J L Breslow, R Ross, ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 14, pp. 133- 140 ,(1994) , 10.1161/01.ATV.14.1.133
Sean B. Joseph, Michelle N. Bradley, Antonio Castrillo, Kevin W. Bruhn, Puiying A. Mak, Liming Pei, John Hogenesch, Ryan M. O'Connell, Genhong Cheng, Enrique Saez, Jeffery F. Miller, Peter Tontonoz, LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response Cell. ,vol. 119, pp. 299- 309 ,(2004) , 10.1016/J.CELL.2004.09.032
Mitsuhiro Watanabe, Sander M. Houten, Li Wang, Antonio Moschetta, David J. Mangelsdorf, Richard A. Heyman, David D. Moore, Johan Auwerx, Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. Journal of Clinical Investigation. ,vol. 113, pp. 1408- 1418 ,(2004) , 10.1172/JCI21025
J D Horton, I Shimomura, M S Brown, R E Hammer, J L Goldstein, H Shimano, Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. Journal of Clinical Investigation. ,vol. 101, pp. 2331- 2339 ,(1998) , 10.1172/JCI2961
Elyisha A. Hanniman, Gilles Lambert, Tanya C. McCarthy, Christopher J. Sinal, Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice. Journal of Lipid Research. ,vol. 46, pp. 2595- 2604 ,(2005) , 10.1194/JLR.M500390-JLR200
Stefano Fiorucci, Elisabetta Antonelli, Giovanni Rizzo, Barbara Renga, Andrea Mencarelli, Luisa Riccardi, Stefano Orlandi, Roberto Pellicciari, Antonio Morelli, The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis Gastroenterology. ,vol. 127, pp. 1497- 1512 ,(2004) , 10.1053/J.GASTRO.2004.08.001