Parosteal osteosarcoma: a monocentric retrospective analysis of 195 patients
作者： Poosit Ruengwanichayakun , Marco Gambarotti , Tommaso Frisoni , Dino Gibertoni , Federica Guaraldi
DOI: 10.1016/J.HUMPATH.2019.05.009
关键词: Tibia 、 Parosteal osteosarcoma 、 Osteosarcoma 、 Humerus 、 Surgery 、 Medullary cavity 、 Retrospective analysis 、 Orthopedic surgery 、 Femur 、 Medicine
摘要: Summary Parosteal osteosarcoma is a low-grade malignant bone tumor that can undergo dedifferentiation. The aim of this study was to analyze clinicopathologic features associated with clinical outcome in large cohort patients. Patients consecutively treated for parosteal at Rizzoli Orthopedic Institute from 1900 2018 were reviewed and analyzed. Clincopathologic data 195 patients Age diagnosis ranged 9 75 years (median 31). Median follow-up time 150 months (range, 3-720). most common locations femur (61.5%), humerus (15.9%) tibia (12.8%). Wide surgical margins achieved 125 (64.1%) Medullary involvement present 69 (35.4%) cases. Dedifferentiation occurred 48 (24.6%) Forty-five developed recurrence (23.1%; median 36 months). At last follow-up, 155 (79.5%) alive without evidence disease, 8 (4.1%) active 23 (11.8%) died (4.6%) unrelated causes. dedifferentiated had worse 5-year (65% versus 96%) 10-year survival (60% when compared conventional tumors (P
elsevier.com
sci-hub.se 参考文章(20)
K Okada, F J Frassica, F H Sim, J W Beabout, J R Bond, K K Unni, Parosteal osteosarcoma. A clinicopathological study Journal of Bone and Joint Surgery, American Volume. ,vol. 76, pp. 366- 378 ,(1994) , 10.2106/00004623-199403000-00007
Kyoji Okada, K. Krishnan Unni, Ronald G. Swee, Franklin H. Sim, High grade surface osteosarcoma: a clinicopathologic study of 46 cases. Cancer. ,vol. 85, pp. 1044- 1054 ,(1999) , 10.1002/(SICI)1097-0142(19990301)85:5<1044::AID-CNCR6>3.0.CO;2-A
W F Enneking, S S Spanier, M A Goodman, Current concepts review. The surgical staging of musculoskeletal sarcoma. The Journal of Bone & Joint Surgery. ,vol. 62, pp. 1027- 1030 ,(1980) , 10.2106/00004623-198062060-00028
L E Wold, K K Unni, J W Beabout, F H Sim, D C Dahlin, Dedifferentiated parosteal osteosarcoma. Journal of Bone and Joint Surgery, American Volume. ,vol. 66, pp. 53- 59 ,(1984) , 10.2106/00004623-198466010-00008
Akihiko Yoshida, Tetsuo Ushiku, Toru Motoi, Tatsuhiro Shibata, Yasuo Beppu, Masashi Fukayama, Hitoshi Tsuda, Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics Modern Pathology. ,vol. 23, pp. 1279- 1288 ,(2010) , 10.1038/MODPATHOL.2010.124
Dhiren S. Sheth, Alan W. Yasko, A. Kevin Raymond, Alberto G. Ayala, C. H. Carrasco, Robert S. Benjamin, Norman Jaffe, John A. Murray, Conventional and dedifferentiated parosteal osteosarcoma : Diagnosis, treatment, and outcome Cancer. ,vol. 78, pp. 2136- 2145 ,(1996) , 10.1002/(SICI)1097-0142(19961115)78:10<2136::AID-CNCR14>3.0.CO;2-#
K. Krishnan Unni, Osteosarcoma of bone Journal of Orthopaedic Science. ,vol. 3, pp. 287- 294 ,(1998) , 10.1007/S007760050055
Franco Bertoni, Patrizia Bacchini, Eric L. Staals, Peter Davidovitz, Dedifferentiated parosteal osteosarcoma: The experience of the Rizzoli Institute Cancer. ,vol. 103, pp. 2373- 2382 ,(2005) , 10.1002/CNCR.21039
Ajay Puri, Manish Pruthi, Saral Desai, Ashish Gulia, Oncological and functional outcome of periosteal osteosarcoma. Indian Journal of Orthopaedics. ,vol. 48, pp. 279- 284 ,(2014) , 10.4103/0019-5413.132518
Laure A E Duhamel, Hongtao Ye, Dina Halai, Bernadine D Idowu, Nadège Presneau, Roberto Tirabosco, Adrienne M Flanagan, Frequency of Mouse Double Minute 2 (MDM2) and Mouse Double Minute 4 (MDM4) amplification in parosteal and conventional osteosarcoma subtypes. Histopathology. ,vol. 60, pp. 357- 359 ,(2012) , 10.1111/J.1365-2559.2011.04023.X