作者: Jerome Engel
DOI: 10.1007/978-1-4615-5375-5_33
关键词: Epileptogenesis 、 Kindling model 、 Neuroscience 、 Epilepsy 、 Stimulus (physiology) 、 Mesial temporal lobe epilepsy 、 Temporal lobe 、 Kindling 、 Hippocampal sclerosis 、 Medicine
摘要: For almost three decades kindling has been a popular experimental tool for investigating enduring changes in neuronal excitability that presumably utilize natural mechanisms underlying normal as well abnormal behaviors. The most common rationale its use presumed relevance to human epileptogenesis, and it referred by many “the model of epilepsy.” Strictly speaking, however, routine is not epilepsy, because animals do experience spontaneous seizures. Nevertheless, clearly occur increasingly dispose specific brain regions generate epileptic seizures, given an appropriate stimulus.