The Syndrome of Mesial Temporal Lobe Epilepsy

作者: Jerome Engel

DOI: 10.1007/978-1-4615-5375-5_33

关键词: EpileptogenesisKindling modelNeuroscienceEpilepsyStimulus (physiology)Mesial temporal lobe epilepsyTemporal lobeKindlingHippocampal sclerosisMedicine

摘要: For almost three decades kindling has been a popular experimental tool for investigating enduring changes in neuronal excitability that presumably utilize natural mechanisms underlying normal as well abnormal behaviors. The most common rationale its use presumed relevance to human epileptogenesis, and it referred by many “the model of epilepsy.” Strictly speaking, however, routine is not epilepsy, because animals do experience spontaneous seizures. Nevertheless, clearly occur increasingly dispose specific brain regions generate epileptic seizures, given an appropriate stimulus.

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