Oxabicycloheptanes and oxabicycloheptenes for the treatment of diabetes

作者: John S. Kovach

DOI:

关键词: EndocrinologyProtein phosphatase 2Mammalian cellDiabetes mellitusInsulin sensitivityPhosphatase 2ACellChemistryBiochemistryInternal medicineA protein

摘要: A method of increasing the insulin sensitivity a mammalian cell by contacting with protein phosphatase 2A (PP2A) inhibitor having structure (I).

参考文章(32)
Sri Devi Narasimhan, Srivatsan Padmanabhan, Heidi A. Tissenbaum, Arnab Mukhopadhyay, Methods for identifying modulators of the pp2a b56 beta regulatory subunit ,(2009)
Kovach John S, Johnson Francis, Samudrala Ramakrishna, SANGUINARINE ANALOG PP2C INHIBITORS FOR CANCER TREATMENT ,(2016)
Satoshi Ugi, Takeshi Imamura, Hiroshi Maegawa, Katsuya Egawa, Takeshi Yoshizaki, Kun Shi, Toshiyuki Obata, Yousuke Ebina, Atsunori Kashiwagi, Jerrold M. Olefsky, Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Molecular and Cellular Biology. ,vol. 24, pp. 8778- 8789 ,(2004) , 10.1128/MCB.24.19.8778-8789.2004
Angela Ladurner, Christoph A. Schmitt, Daniel Schachner, Atanas G. Atanasov, Ernst R. Werner, Verena M. Dirsch, Elke H. Heiss, Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status. Free Radical Biology and Medicine. ,vol. 52, pp. 2082- 2090 ,(2012) , 10.1016/J.FREERADBIOMED.2012.03.022
Min Han, Suresh Pendem, Suet Ling Teh, Dinesh K. Sukumaran, Feng Wu, John X. Wilson, Ascorbate protects endothelial barrier function during septic insult: Role of protein phosphatase type 2A Free Radical Biology and Medicine. ,vol. 48, pp. 128- 135 ,(2010) , 10.1016/J.FREERADBIOMED.2009.10.034
Gang Zhou, George Kamenos, Suresh Pendem, John X. Wilson, Feng Wu, Ascorbate protects against vascular leakage in cecal ligation and puncture-induced septic peritonitis American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 302, ,(2012) , 10.1152/AJPREGU.00153.2011
James M. May, Zhi-chao Qu, Nitric oxide mediates tightening of the endothelial barrier by ascorbic acid. Biochemical and Biophysical Research Communications. ,vol. 404, pp. 701- 705 ,(2011) , 10.1016/J.BBRC.2010.12.046
Yong Wu, Ping Song, Jian Xu, Miao Zhang, Ming-Hui Zou, Activation of Protein Phosphatase 2A by Palmitate Inhibits AMP-activated Protein Kinase Journal of Biological Chemistry. ,vol. 282, pp. 9777- 9788 ,(2007) , 10.1074/JBC.M608310200
Thomas Galbo, Grith Skytte Olsen, Bjørn Quistorff, Erica Nishimura, Free Fatty Acid-Induced PP2A Hyperactivity Selectively Impairs Hepatic Insulin Action on Glucose Metabolism PLoS ONE. ,vol. 6, pp. e27424- ,(2011) , 10.1371/JOURNAL.PONE.0027424