Identification of distinct physiochemical properties of toxic prefibrillar species formed by Aβ peptide variants.

作者: Anna-Lena Göransson , K. Peter R. Nilsson , Katarina Kågedal , Ann-Christin Brorsson

DOI: 10.1016/J.BBRC.2012.03.097

关键词: P3 peptideBiochemistryCell toxicityChemistryPeptideAβ peptideProtein aggregationAmyloid β peptide

摘要: The formation of amyloid-β peptide (Aβ) aggregates at an early stage during the self-assembly process is important factor in development Alzheimer’s disease. toxic effect believed ...

参考文章(15)
Harry LeVine, QUANTIFICATION OF BETA -SHEET AMYLOID FIBRIL STRUCTURES WITH THIOFLAVIN T Methods in Enzymology. ,vol. 309, pp. 274- 284 ,(1999) , 10.1016/S0076-6879(99)09020-5
Samir Kumar-Singh, Jessie Theuns, Bianca Van Broeck, Daniel Pirici, Krist'l Vennekens, Ellen Corsmit, Marc Cruts, Bart Dermaut, Rong Wang, Christine Van Broeckhoven, Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40†‡§ Human Mutation. ,vol. 27, pp. 686- 695 ,(2006) , 10.1002/HUMU.20336
Wei-Feng Xue, Andrew L. Hellewell, Walraj S. Gosal, Steve W. Homans, Eric W. Hewitt, Sheena E. Radford, Fibril fragmentation enhances amyloid cytotoxicity. Journal of Biological Chemistry. ,vol. 284, pp. 34272- 34282 ,(2009) , 10.1074/JBC.M109.049809
Camilla Nilsberth, Anita Westlind-Danielsson, Christopher B. Eckman, Margaret M. Condron, Karin Axelman, Charlotte Forsell, Charlotte Stenh, Johan Luthman, David B. Teplow, Steven G. Younkin, Jan Näslund, Lars Lannfelt, The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation Nature Neuroscience. ,vol. 4, pp. 887- 893 ,(2001) , 10.1038/NN0901-887
Silvia Campioni, Benedetta Mannini, Mariagioia Zampagni, Anna Pensalfini, Claudia Parrini, Elisa Evangelisti, Annalisa Relini, Massimo Stefani, Christopher M Dobson, Cristina Cecchi, Fabrizio Chiti, A causative link between the structure of aberrant protein oligomers and their toxicity Nature Chemical Biology. ,vol. 6, pp. 140- 147 ,(2010) , 10.1038/NCHEMBIO.283
Benedetta Bolognesi, Janet R. Kumita, Teresa P. Barros, Elin K. Esbjorner, Leila M. Luheshi, Damian C. Crowther, Mark R. Wilson, Christopher M. Dobson, Giorgio Favrin, Justin J. Yerbury, ANS Binding Reveals Common Features of Cytotoxic Amyloid Species ACS Chemical Biology. ,vol. 5, pp. 735- 740 ,(2010) , 10.1021/CB1001203
Dominic M. Walsh, Aleksey Lomakin, George B. Benedek, Margaret M. Condron, David B. Teplow, Amyloid β-Protein Fibrillogenesis: DETECTION OF A PROTOFIBRILLAR INTERMEDIATE Journal of Biological Chemistry. ,vol. 272, pp. 22364- 22372 ,(1997) , 10.1074/JBC.272.35.22364
K. Peter R. Nilsson, Per Hammarström, Rozalyn Simon, Sofie Nyström, Peter Konradsson, Andreas Åslund, A Fluorescent Pentameric Thiophene Derivative Detects in Vitro-Formed Prefibrillar Protein Aggregates Biochemistry. ,vol. 49, pp. 6838- 6845 ,(2010) , 10.1021/BI100922R
James P Cleary, Dominic M Walsh, Jacki J Hofmeister, Ganesh M Shankar, Michael A Kuskowski, Dennis J Selkoe, Karen H Ashe, Natural oligomers of the amyloid-|[beta]| protein specifically disrupt cognitive function Nature Neuroscience. ,vol. 8, pp. 79- 84 ,(2005) , 10.1038/NN1372