Role of temperature in regulation of spermatogenesis and the use of heating as a method for contraception

作者: Edward E. Wallach , Fouad R. Kandeel , Ronald S. Swerdloff

DOI: 10.1016/S0015-0282(16)59640-X

关键词: Sensory inputAndrologyBiologySpermatogenesisSpermMale fertilitySemenBody core temperaturePopulationMale genitalia

摘要: A large body of research confirms the vulnerable nature spermatogenesis to relatively small increases in testicular temperature. Other physical properties electromagnetic and ultrasound waves have additive or synergistic effects those heat allow disruption spermatogenic processes at minimal temperature elevations. In addition there is a rebound sperm count following heat-induced suppression spermatogenesis. These findings suggest theoretical viability heating as reversible method male contraception humans. However before techniques can be used for fertility control several questions remain investigated. The lowest effective doses frequency application each necessary inducing maintaining reliable infertile state must established. It determined whether long-term exposure leads permanent damage compromise elements functions simple induces significant changes biological constituents human semen. Also unclear exact mutagenic potential thermal agents on gonads. Another question scrotal warm sensory input rises during level that sufficient alter core Rapidly advancing knowledge biologic semen increasingly available detection methods these will enhance areas. through such safety efficacy applicability manipulation established refuted.

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