Levels of catecholamine in plasma and cerebrospinal fluid in aneurysmal subarachnoid hemorrhage.

摘要: Despite intensive investigation into the cause of cerebral vasospasm (focal ischemic deficit) after subarachnoid hemorrhage, morbidity and mortality associated with this condition remain high. Various studies have shown levels catecholamine in plasma cerebrospinal fluid (CSF) to be increased it is possible that these vasoactive substances play an important role subsequent vasospasm. In attempt elucidate possibility, study presented here was undertaken investigate relationship between CSF focal deficit (FID); rupture aneurysms on blood vessels supplying hypothalamus as compared other areas brain; clinical outcome patients. Concentrations adrenaline noradrenaline samples obtained from 21 patients who had suffered aneurysmal hemorrhage were determined by a radioenzymatic technique. Significantly higher found at time surgery FID. A similar trend, though not statistically significant, also observed for plasma. Patients showed tendency towards CSF. Subjects bad (i.e., those severely disabled or died) significantly than did good moderate no disability). Further detailed analysis interrelationships that, within group FID, vessels. Furthermore, hypothalamus, outcome. These findings lend support possibility damage elevations may FID poor