The cellular microenvironment: a new target in the search for cellular and molecular treatment for Dupuytren’s disease

摘要: Introduction: Dupuytren’s disease (DD) is a debilitating fibrotic of the palmar fascia (PF) that leads to irreversible flexion contractures fingers and loss dexterity hand function. Currently, DD treated by surgical or enzymatic elimination contracted PF using treatment approaches carry significant morbidity high recurrence rates.Areas covered: This review limited most recent data pertaining cellular molecular biology DD. It does not on clinical management DD.Expert opinion: The current gold standard (sub)-total resection diseased, fascia. Like other less invasive alternatives, such as needle aponeurotomy clostridial collagenase digestion cords, fasciectomy associated with rates. summarizes published evidence changes in microenvironment can modify established signaling pathways gene...