Long-term increases in lymphocytes and platelets in human T-lymphotropic virus type II infection

摘要: Human T-lymphotropic viruses types I and II (HTLV-I HTLV-II) cause chronic infections of T lymphocytes that may lead to leukemia myelopathy. However, their long-term effects on blood counts hematopoiesis are poorly understood. We followed 151 HTLV-I-seropositive, 387 HTLV-II-seropositive, 799 HTLV-seronegative former donors from 5 U.S. centers for a median 14.0 years. Complete were performed every 2 Multivariable repeated measures analyses conducted evaluate the independent effect HTLV infection potential confounders 9 hematologic measurements. Participants with HTLV-II had significant (P < .05) increases in adjusted lymphocyte (+126 cells/mm(3); approximately +7%), hemoglobin (+2 g/L [+0.2 g/dL]) mean corpuscular volume (MCV; 1.0 fL) compared seronegative participants. HTLV-I higher platelet (+16 544 +21 657 P than seronegatives. Among all participants, time led decreases count counts, MCV monocytes. Sex, race, smoking, alcohol consumption counts. The is novel be related viral transactivation or immune response. associations suggest hematopoietic growth factors cytokines.