Pharmacology and toxicology of COX-2 inhibitors
作者： K. D. Rainsford
DOI: 10.1007/978-3-0348-7879-1_4
关键词: Isozyme 、 Housekeeping 、 ATP synthase 、 Inflammation 、 Pharmacology 、 Medicine 、 Gene 、 Adjuvant arthritis 、 Prostaglandin 、 Enzyme
摘要: The pharmacological premise upon which the prostaglandin G/H synthase II (PGHS-II) or cyclo-oxygenase-2 (COX-2) inhibitors was developed essentially that founded in identification of two different genes coding for cyclo-oxygenases-1 and -2 [1–3]. COX-1 is considered to be a constitutive enzyme responsible “housekeeping” physiological functions (e.g., some gastrointestinal (GI) mucosal, renal haemostatic protective effects) while COX-2, induced by inflammatory stimuli, important inflammation, pain fever [1–5]. Comprehensive reviews on regulation roles these isoenzymes inflammation are found [1–9] Figure 1 summarizes their essential features.
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