Liver Iron Concentration in Patients Referred to a Secondary Hospital for Hyperferritinemia: Analysis of the Different Groups According to HFE Mutations and the Transferrin Saturation Index

摘要: Background: Olynyk et al. studied the liver iron concentration (LIC) by MRI of 52 consecutive patients northern European origin who were referred to a tertiary hospital for hyperferritinemia (HF). They described three groups according HFE mutations and transferrin saturation index (TSI) (group A: no predisposing (PM) hereditary hemochromatosis (HH) TSI > 45 %, group B: PM HH %; C: normal TSI). In Basque country, differ, with prevalence H63D/H63D mutation. Objectives: To study importance in determining LIC HF attending outpatient clinic at secondary hospital. Methods: Prospective 132 HF. 120 was available. 79 obtained MRI. 71 values mutations, TSI, Results: Mean age: 55.68 ± 14.26 (23 - 83), 55 men 16 women. The mean 35.66 36.85; women 38.81 29.75. 38.80 45.18 (5 210), 48.96 37.51 (15 160), 28.12 18.85 75). We compared 3 significant differences. Conclusions: are similar different HF, despite variable predisposition HH.