In vitro and in vivo inhibition of lysyl oxidase byaminopropionitriles
作者： Kenneth R. Wilmarth , John R. Froines
DOI: 10.1080/15287399209531680
关键词: Biology 、 Lysyl oxidase 、 Elastin 、 Biochemistry 、 Enzyme 、 Osteolathyrism 、 Enzyme assay 、 Mechanism of action 、 In vivo 、 In vitro
摘要: Inhibition of lysyl oxidase (protein‐lysine 6‐oxidase, EC 1.4.3.13) decreases the rate collagen and elastin cross‐link formation produces osteolathyrism in animals. Organic nitriles, including s‐aminopropionitrile (BAPN), have been shown to irreversibly inhibit vitro. Both BAPN 3,3'‐iminodipropionitrile (IDPN) produce osteolathyric changes when administered To date compounds that reported this enzyme possess a primary amine functional group. In study series substituted aminopropionitriles was studied for their ability activity both vitro vivo. Our results show tested, most potent inhibitor enzyme. Reversible inhibition found with two secondary aminonitriles, IDPN monomethy‐laminopropionitrile (MMAPN). There no associated tertiary compound 3,3'‐dimethylam...
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