KCNQ5, a Novel Potassium Channel Broadly Expressed in Brain, Mediates M-type Currents
作者： Björn C. Schroeder , Mirko Hechenberger , Frank Weinreich , Christian Kubisch , Thomas J. Jentsch
关键词: Cell biology 、 Superior cervical ganglion 、 KCNQ2 Potassium Channel 、 Electrophysiology 、 Depolarization 、 Skeletal muscle 、 Potassium channel 、 Endocrinology 、 Membrane potential 、 M current 、 Internal medicine 、 Biology
摘要: KCNQ2 and KCNQ3, both of which are mutated in a type human neonatal epilepsy, form heteromeric potassium channels that expressed broad regions the brain. The associated current may be identical to M-current, an important regulator neuronal excitability. We now show RNA encoding novel KCNQ5 channel is also brain sympathetic ganglia where it overlaps largely with KCNQ3. In addition, skeletal muscle. yields currents activate slowly depolarization can Currents from have voltage dependences inhibitor sensitivities common M-currents. They inhibited by M1 muscarinic receptor activation. A splice variant found muscle displays altered gating kinetics. This indicates molecular diversity yielding M-type suggests role for regulation
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leibniz-fmp.de参考文章(44)
Hong-Sheng Wang, Zongming Pan, Wenmei Shi, Barry S Brown, Randy S Wymore, Ira S Cohen, Jane E Dixon, David McKinnon, KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel Science. ,vol. 282, pp. 1890- 1893 ,(1998) , 10.1126/SCIENCE.282.5395.1890
T. Kharkovets, J.-P. Hardelin, S. Safieddine, M. Schweizer, A. El-Amraoui, C. Petit, T. J. Jentsch, KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 4333- 4338 ,(2000) , 10.1073/PNAS.97.8.4333
M. C. Sanguinetti, M. E. Curran, A. Zou, J. Shen, P. S. Specter, D. L. Atkinson, M. T. Keating, Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature. ,vol. 384, pp. 80- 83 ,(1996) , 10.1038/384080A0
Michael Pusch, Raffaella Magrassi, Bernd Wollnik, Franco Conti, Activation and inactivation of homomeric KvLQT1 potassium channels Biophysical Journal. ,vol. 75, pp. 785- 792 ,(1998) , 10.1016/S0006-3495(98)77568-X
Lise Heginbotham, Roderick MacKinnon, The aromatic binding site for tetraethylammonium ion on potassium channels Neuron. ,vol. 8, pp. 483- 491 ,(1992) , 10.1016/0896-6273(92)90276-J
C. Lorenz, M. Pusch, T. J. Jentsch, Heteromultimeric CLC chloride channels with novel properties Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 13362- 13366 ,(1996) , 10.1073/PNAS.93.23.13362
Christian Kubisch, Björn C Schroeder, Thomas Friedrich, Björn Lütjohann, Aziz El-Amraoui, Sandrine Marlin, Christine Petit, Thomas J Jentsch, KCNQ4, a Novel Potassium Channel Expressed in Sensory Outer Hair Cells, Is Mutated in Dominant Deafness Cell. ,vol. 96, pp. 437- 446 ,(1999) , 10.1016/S0092-8674(00)80556-5
Christophe Chouabe, Nathalie Neyroud, Pascale Guicheney, Michel Lazdunski, Georges Romey, Jacques Barhanin, Properties of KvLQT1 K+ channel mutations in Romano–Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias The EMBO Journal. ,vol. 16, pp. 5472- 5479 ,(1997) , 10.1093/EMBOJ/16.17.5472
M.-C. Tsai, J.-L. Su, M.-L. Chen, S.-Z. Fan, C.-Y. Cheng, The effect of 3,3-dipyridylmethyl-1-phenyl-2-indolinone on the neuromuscular transmission in the rodent skeletal muscles. Neuropharmacology. ,vol. 31, pp. 89- 94 ,(1992) , 10.1016/0028-3908(92)90166-M
Norbert Tinel, Inger Lauritzen, Christophe Chouabe, Michel Lazdunski, Marc Borsotto, The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3 FEBS Letters. ,vol. 438, pp. 171- 176 ,(1998) , 10.1016/S0014-5793(98)01296-4