Subthalamic nucleus stimulation affects incentive salience attribution in Parkinson's disease.

摘要: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can induce nonmotor side effects such as behavioral and mood disturbances or body weight gain in Parkinson's disease (PD) patients. We hypothesized that some these problems could be related to an altered attribution incentive salience (ie, emotional relevance) rewarding aversive stimuli. Twenty PD patients (all men; mean age 6 SD, 58.3 years) bilateral STN DBS switched ON OFF con- ditions 18 matched controls rated pictures selected from International Affective Picture System accord- ing valence (unpleasantness/pleasantness) arousal on 2 independent visual scales ranging 1 9. Eighty-four depicting primary (erotica food) fearful (vic- tims threat) neutral stimuli were for this study. In condition, attributed lower scores compared with condition (P <.01) < .01). The difference between was less pro- nounced .05). Furthermore, postoperative correlated ratings food pic- tures .05 compen- sated condition). Our results suggest increases activation motivational system so more relevance is addition, DBS-related sensitivity reward cues might drive DBS-treated higher intake subsequent gain. V C 2011 Movement Disorder Society