The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson's disease.

作者: Jessica Y. Vargas , Clara Grudina , Chiara Zurzolo

DOI: 10.1016/J.ARR.2019.01.012

关键词: In vitroα synucleinNeurodegenerationDopaminergicDiseaseParkinson's diseaseNeurosciencePrion proteinIn vivoBiology

摘要: … inside neurons and propagates from cell-to-cell in a prion-like … -microbiota axis interactions in PD pathology and to identify peripheral biomarkers within the enteric nervous system that …

参考文章(137)
Kelvin C Luk, Cheng Song, Patrick O'Brien, Anna Stieber, Jonathan R Branch, Kurt R Brunden, John Q Trojanowski, Virginia M-Y Lee, Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 20051- 20056 ,(2009) , 10.1073/PNAS.0908005106
Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A.I de Vos, Ernst N.H Jansen Steur, Eva Braak, Staging of brain pathology related to sporadic Parkinson’s disease Neurobiology of Aging. ,vol. 24, pp. 197- 211 ,(2003) , 10.1016/S0197-4580(02)00065-9
Juan F. Reyes, Tomas T. Olsson, Jennifer T. Lamberts, Michael J. Devine, Tilo Kunath, Patrik Brundin, A cell culture model for monitoring α-synuclein cell-to-cell transfer Neurobiology of Disease. ,vol. 77, pp. 266- 275 ,(2015) , 10.1016/J.NBD.2014.07.003
Laura A. Volpicelli-Daley, Kelvin C. Luk, Tapan P. Patel, Selcuk A. Tanik, Dawn M. Riddle, Anna Stieber, David F. Meaney, John Q. Trojanowski, Virginia M.-Y. Lee, Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron. ,vol. 72, pp. 57- 71 ,(2011) , 10.1016/J.NEURON.2011.08.033
Anne-Laure Mougenot, Simon Nicot, Anna Bencsik, Eric Morignat, Jérémy Verchère, Latefa Lakhdar, Stéphane Legastelois, Thierry Baron, Prion-like acceleration of a synucleinopathy in a transgenic mouse model Neurobiology of Aging. ,vol. 33, pp. 2225- 2228 ,(2012) , 10.1016/J.NEUROBIOLAGING.2011.06.022
Leslie Crews, Brian Spencer, Paula Desplats, Christina Patrick, Amy Paulino, Edward Rockenstein, Lawrence Hansen, Anthony Adame, Douglas Galasko, Eliezer Masliah, Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy PLOS ONE. ,vol. 5, ,(2010) , 10.1371/JOURNAL.PONE.0009313
A. N. Sacino, M. Brooks, A. B. McKinney, M. A. Thomas, G. Shaw, T. E. Golde, B. I. Giasson, Brain Injection of α-Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker The Journal of Neuroscience. ,vol. 34, pp. 12368- 12378 ,(2014) , 10.1523/JNEUROSCI.2102-14.2014
Christina E. Khodr, Amanda Becerra, Ye Han, Martha C. Bohn, Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: positive and negative effects. Brain Research. ,vol. 1550, pp. 47- 60 ,(2014) , 10.1016/J.BRAINRES.2014.01.010
Hans-Hermann Gerdes, Amin Rustom, Xiang Wang, Tunneling nanotubes, an emerging intercellular communication route in development. Mechanisms of Development. ,vol. 130, pp. 381- 387 ,(2013) , 10.1016/J.MOD.2012.11.006