Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS

摘要: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by selective degeneration of motor neurons throughout the central nervous systems. Non-cell autonomous damage induced glial cells linked to susceptibility in ALS, but mechanisms underlying this phenomenon are not known. We found that expression non-phosphorylated and phosphorylated forms (tyrosine (Tyr) residue 905, 1016, 1062) c-Ret, member cell line-derived neurotrophic factor (GDNF) receptor, altered lumbar spinal cord ALS transgenic (G93A) mice line models. Phosphorylated c-Ret were colocalized with neurofilament aggregates mice. Consistent vivo data, levels (Tyr decreased oxidative stress neuronal (NSC-34). Non-phosphorylated immunoreactivity markedly elevated active microglia Our findings suggest constitutive modulates function, thereby reducing GDNF signaling neurons. Furthermore, induction may contribute non-cell death available ALS.