Hypoxia, MTOR and autophagy

摘要: Although hypoxia can cause cell cycle arrest, it may simultaneously suppress a conversion from this arrest to senescence. Furthermore, senescence caused by diverse stimuli, maintaining reversible quiescence instead. Hypoxia activates autophagy and inhibits MTOR, thus also activating autophagy. What is the relationship between cellular senescence? Also, inhibition of MTOR stimulation explain gerosuppressive effects hypoxia?