Malignant transformation of monoclonal gammopathy of undetermined significance among out-patients of a community hospital in southeastern Netherlands.

摘要: Summary Patients with a monoclonal gammopathy without evidence of lymphoproliferative or plasma cell malignancy within year are still at risk for malignant transformation to multiple myeloma, Waldenstrom's macro-globulinaemia non-Hodgkin's lymphoma. In prospective study performed the Mayo Clinic, cumulative incidence was 29% in 14 years. We conducted retrospective determine frequency among 334 un-selected out-patients undetermined significance (MGUS) from community hospital Southeastern Netherlands. The 11% years (95% confidence interval 6–17%). long-term survival patients MGUS slightly lower than that average regional population. nested case-control study, presence kappa light chain found be factor (70% who developed compared 30% control group, P < 001). Likewise, an initial high gamma globulin level also (18–7g/1 v 13–7g/l P<001). As neither has been described before, these factors definition high-risk group remains determined.