Evolution of Virulence in Picornaviruses

摘要: The Picornaviridae encompass many positive-strand RNA viruses, all of which share a generally similar genome design and capsid structure, but induce quite diverse diseases in humans other animals. Picornavirus strains the same serotype have been shown to express different virulence (or pathogenic) phenotypes when studied animal models, demonstrating that key elements pathogenesis reside viral genome. However, genetics determine phenotype any picornavirus are poorly understood. Picornaviruses do not genes perse, howit interacts with virus receptor expressed on host cell surface, specific sequences within nontranslated regions genome, as well coding result protein may part determining phenotype. Virulence be better understood continuum from an apparent inability disease ability cause severe pathogenic changes. Ultimately, depends upon how they modulated by environment.