Statistical approaches for evaluating surrogate outcomes in clinical trials: A systematic review.
作者： Hannah Ensor , Robert J. Lee , Cathie Sudlow , Christopher J. Weir
DOI: 10.1080/10543406.2015.1094811
关键词: Data mining 、 Alternative medicine 、 Treatment effect 、 Clinical trial 、 Outcome (game theory) 、 Medical physics 、 Medicine
摘要: The use of surrogate outcomes that predict treatment effect on an unobserved true outcome may have substantial economic and ethical advantages, through reducing the length size clinical trials. There has been extensive investigation best means evaluating putative surrogates. We present a systematic review evolution statistical methods for validating surrogates starting from defining paper Prentice (1989). highlight fundamental differences in current evaluation approaches, their advantages disadvantages, examine understanding perceptions investigators this area.
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