Efficient molecular encoding in multifunctional self-immolative urethanes

摘要: Summary Molecular encoding in sequence-defined polymers shows promise as a new paradigm for data storage. Here, we report what is, to our knowledge, the first use of self-immolative oligourethanes storing and reading encoded information. As proof principle, describe how text passage from Jane Austen’s Mansfield Park was reconstructed via sequencing. We develop Mol.E-coder, software tool that uses Huffman scheme convert character table hexadecimal. The are then generated by high-throughput parallel synthesis. Sequencing self-immolation is done concurrently fashion, liquid chromatography-mass spectrometry (LC-MS) information decoded Mol.E-decoder software. capable being reproduced wholly intact third-party, without any purifications or tandem MS (MS/MS), despite multiple rounds compression, encoding,