Effects of Dose of Dialysis on Morbidity and Mortality

摘要: The annual mortality rate of patients on hemodialysis in the United States is 24.3%, substantially higher than age-matched Europe and Japan. Differences dose dialysis received by US has been proposed as an important factor contributing to this high rate. We undertook a prospective effort increase delivered 130 treated at urban center affiliated with Vanderbilt University. From 1988 1991 dialysis, represented urea kinetic modelling parameter Kt/V (K = dialyzer clearance, t time, V volume distribution urea), gradually increased from 0.82 +/- 0.32 1.33 0.23. Concurrent increase, there was reduction gross 22.8% 9.1% 1991. To account for potential differences patient characteristics during those years, we also calculated number expected deaths, based data Renal Data System. ratio observed termed "standardized rate," decreased value 1.03 0.611 In addition, hospital days per year 15.2 d/patient/yr 10.3 d/patient/yr. conclude that increasing decreases hospitalization rates hemodialysis-dependent patients.