Primary sclerosing cholangitis. A study of forty-two cases.

摘要: Abstract Forty-two patients with primary sclerosing cholangitis were studied in four groups: twelve who also had ulcerative colitis; fifteen biliary surgery, gallstones found fourteen; severe periportal inflammation; eleven no other intra-abdominal or general disease. Study of the clinical material supports hypothesis bacterial etiology The diagnosis is usually made at operation from characteristic gross appearance bile ducts, namely, thickening and induration duct wall narrowing ductal lumen, involving entire extrahepatic tract majority cases. resemblance pathologic changes to those cholangiocarcinoma pointed out, importance differential these two diseases emphasized. Surgical treatmentm limited decompression tree by external internal drainage, removal stones if present, total colectomy associated colitis. disease carries an unfavorable prognosis, progressing cases cirrhosis death liver failure bleeding esophageal varices within several years its onset.