Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses

摘要: Interleukin-6 (IL-6) is a proinflammatory cytokine of the IL-6 family, members which signal through complex cytokine-specific receptor and signal-transducing subunit gp130. The interaction with membrane-bound (IL-6R) gp130 stimulates “classic signaling,” whereas binding soluble version IL-6R to “trans-signaling.” Alternatively, “cluster signaling” occurs when IL-6:IL-6R complexes on transmitter cells activate receptors neighboring receiver cells. form (sgp130) selective trans-signaling inhibitor, but it does not affect classic signaling. We demonstrated that natural synthetic inhibited cluster Similarly, IL-11 signaling IL-11R was also by However, autocrine extracellular inhibitors such as sgp130 or antibodies. Together, our results suggest may occur intracellularly.