Method and kit for detecting five psychotropic drugs and main metabolites thereof in blood

摘要: The invention belongs to the field of drug detection, and particularly relates a method kit for detecting five psychotropic drugs main metabolites thereof in blood. psychotropicdrugs comprise: olanzapine demethyl olanzapine, risperidone 9-hydroxy risperidone, aripiprazole dehydrogenated aripiprazole, Escitalopram citalopram, sertraline N-demethyl sertraline. Accoridng provided by invention, pair quantitative ion pairs is respectively selected each detection substance, relative retention time used as qualitative basis, standard curve made using product quantification; furthermore, accuracy effectiveness are evaluatedfrom quality control three low, middle high levels, thereby avoiding distortion result; meanwhile, an internal working solution applied correction, so that matrix effects can be avoided, accurate quantification realized. has advantages simple rapid operation, flux low cost, appliedto therapeutic monitoring clinical work psychiatry department.