Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial).

作者: Liv Vossen , Leon Schurgers , Bernard van Varik , Bas Kietselaer , Cees Vermeer

DOI: 10.3390/NU7115443

关键词: Clinical endpointPathogenesisVitaminCalcificationMatrix gla proteinCoronary artery diseaseVitamin K2Arterial calcificationMedicineInternal medicineCardiologyPathology

摘要: Coronary artery calcification (CAC) develops early in the pathogenesis of atherosclerosis and is a strong independent predictor cardiovascular disease (CVD). Arterial caused by an imbalance regulatory mechanisms. An important inhibitor vitamin K-dependent matrix Gla protein (MGP). Both preclinical clinical studies have shown that inhibition K-cycle K antagonists (VKA) results elevated uncarboxylated MGP (ucMGP) subsequently extensive arterial calcification. This led us to hypothesize supplementation may slow down progression To test this, we designed VitaK-CAC trial which analyses effects menaquinone-7 (MK-7) on CAC. The double-blind, randomized, placebo-controlled including patients with coronary (CAD). Patients baseline Agatston CAC-score between 50 400 will be randomized intervention-group (360 microgram MK-7) or placebo group. Treatment duration 24 months. primary endpoint difference both groups. Secondary endpoints include changes structure function, associations biomarkers. We treatment MK-7 arrest CAC this lead option for vascular subsequent CVD.

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