EGFR Promotes Lung Tumorigenesis by Activating miR-7 through a Ras/ERK/Myc Pathway That Targets the Ets2 Transcriptional Repressor ERF
作者： Yu-Ting Chou , Hua-Heng Lin , Yung-Chang Lien , Yuan-Hung Wang , Chun-Fu Hong
DOI: 10.1158/0008-5472.CAN-10-0638
关键词: Epidermal growth factor receptor 、 Ectopic expression 、 Oncomir 、 Signal transduction 、 microRNA 、 Cancer research 、 MAPK/ERK pathway 、 Carcinogenesis 、 Biology 、 Lung cancer
摘要: MicroRNAs (miRNA) mediate distinct gene regulatory pathways triggered by epidermal growth factor receptor (EGFR) activation, which occurs commonly in lung cancers with poor …
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researchgate.net 参考文章(37)
D. N. Sgouras, M. A. Athanasiou, G. J. Beal, R. J. Fisher, D. G. Blair, G. J. Mavrothalassitis, ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. The EMBO Journal. ,vol. 14, pp. 4781- 4793 ,(1995) , 10.1002/J.1460-2075.1995.TB00160.X
A. Jemal, R. Siegel, E. Ward, T. Murray, J. Xu, C. Smigal, M. J. Thun, Cancer statistics, 2006. CA: A Cancer Journal for Clinicians. ,vol. 56, pp. 106- 130 ,(2006) , 10.3322/CANJCLIN.56.2.106
Mihalis Verykokakis, Chara Papadaki, Elena Vorgia, Lionel Le Gallic, George Mavrothalassitis, The RAS-dependent ERF Control of Cell Proliferation and Differentiation Is Mediated by c-Myc Repression Journal of Biological Chemistry. ,vol. 282, pp. 30285- 30294 ,(2007) , 10.1074/JBC.M704428200
D Irmer, J O Funk, A Blaukat, EGFR kinase domain mutations - functional impact and relevance for lung cancer therapy. Oncogene. ,vol. 26, pp. 5693- 5701 ,(2007) , 10.1038/SJ.ONC.1210383
Kathryn A. O'Donnell, Erik A. Wentzel, Karen I. Zeller, Chi V. Dang, Joshua T. Mendell, c-Myc-regulated microRNAs modulate E2F1 expression. Nature. ,vol. 435, pp. 839- 843 ,(2005) , 10.1038/NATURE03677
Pedro P. Medina, Frank J. Slack, microRNAs and cancer: an overview. Cell Cycle. ,vol. 7, pp. 2485- 2492 ,(2008) , 10.4161/CC.7.16.6453
María José Bueno, Ignacio Pérez de Castro, Marcos Malumbres, Control of cell proliferation pathways by microRNAs Cell Cycle. ,vol. 7, pp. 3143- 3148 ,(2008) , 10.4161/CC.7.20.6833
Kelly D. Hester, Dominique Verhelle, Laure Escoubet-Lozach, Rosa Luna, David W. Rose, Christopher K. Glass, Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS. Cell Cycle. ,vol. 6, pp. 1594- 1604 ,(2007) , 10.4161/CC.6.13.4336
Xin Li, Justin J. Cassidy, Catherine A. Reinke, Stephen Fischboeck, Richard W. Carthew, A MicroRNA Imparts Robustness against Environmental Fluctuation during Development Cell. ,vol. 137, pp. 273- 282 ,(2009) , 10.1016/J.CELL.2009.01.058
E. Junn, K.-W. Lee, B. S. Jeong, T. W. Chan, J.-Y. Im, M. M. Mouradian, Repression of α-synuclein expression and toxicity by microRNA-7 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 13052- 13057 ,(2009) , 10.1073/PNAS.0906277106