Biomechanical Screening of Cell Therapies for Vocal Fold Scar
作者： Rebecca S. Bartlett , Joel D. Gaston , Tom Y. Yen , Shuyun Ye , Christina Kendziorski
DOI: 10.1089/TEN.TEA.2015.0168
关键词: Adipose tissue 、 Bone marrow 、 Tissue engineering 、 Cell biology 、 Cell 、 Wound healing 、 Biology 、 Cellular differentiation 、 Mesenchymal stem cell 、 Pathology 、 Microarray
摘要: Candidate cell sources for vocal fold scar treatment include mesenchymal stromal cells from bone marrow (BM-MSC) and adipose tissue (AT-MSC). Mechanosensitivity of MSC can alter highly relevant aspects their behavior, yet virtually nothing is known about how might respond to the dynamic mechanical environment larynx. Our objective was evaluate as a potential source engineering in mechanically context. A vibratory strain bioreactor cDNA microarray were used similarity AT-MSC BM-MSC native source, fibroblasts (VFF). Posterior probabilities each transcripts fitting into specific expression patterns calculated, data analyzed Gene Ontology (GO) enrichment. Significant wound healing differentiation GO terms are reported. In addition, proliferation apoptosis evaluated with immunohistochemistry. Results revealed that VFF shared more rel...
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